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Lanthanide(III) Complexes of Tris(amide) PCTA Derivatives as Potential Bimodal Magnetic Resonance and Optical Imaging Agents |
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| Authors: | Federico A. Rojas‐Quijano Dr. Enikő Tircsóné Benyó Gyula Tircsó Dr. Ferenc K. Kálmán Dr. Zsolt Baranyai Dr. Silvio Aime Prof. A. Dean Sherry Prof. Zoltán Kovács Prof. |
| Affiliation: | 1. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 (USA), Fax: (+1)?214‐645‐2744;2. Department of Inorganic and Analytical Chemistry, University of Debrecen, 4010, Debrecen, Egyetem tér 1. (Hungary);3. Department of Chemistry IFM & Molecular Imaging Center, Università degli Studi di Torino, Via P. Giuria 7, 10125 Torino (Italy) |
| Abstract: | Lanthanide complexes of two tris(amide) derivatives of PCTA were synthesized and characterized. The relaxometric and luminescence properties of their lanthanide complexes were investigated as bimodal magnetic resonance (MR) and optical imaging agents. Luminescence studies show that one of the TbIII complexes dimerizes in solution at low millimolar concentrations, whereas the other may have a higher than expected coordination number in solution. The corresponding GdIII complexes display unusually high T1 relaxivities and enhanced kinetic inertness compared to GdPCTA. These features suggest that these new chelates may be suitable for in vivo applications. The fast water‐exchange rates observed for these complexes make them unsuitable as paramagnetic chemical exchange saturation transfer (PARACEST) agents. |
| Keywords: | imaging agents lanthanides PARACEST water chemistry |