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Acceleration of Reductive Elimination of [Ar‐Pd‐C] by a Phosphine/Electron‐Deficient Olefin Ligand: A Kinetic Investigation |
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| Authors: | Heng Zhang Dr Xiancai Luo Kittiya Wongkhan Hui Duan Qiang Li Lizheng Zhu Jian Wang Dr Andrei S Batsanov Dr Judith A K Howard Prof Dr Todd B Marder Prof Dr Aiwen Lei Prof Dr |
| Institution: | 1. College of Chemistry and Molecular Sciences, Wuhan University, 430072 (P. R. China), Fax: (+86)?27‐68754067;2. Department of Chemistry, Durham University, South Road, Durham DH1 3 LE (UK);3. Real‐Time Analytics, Mettler Toledo Auto Chem, 7075 Samuel Morse Dr., Columbia, MD 21046 (USA);4. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Acadamy of Sciences, 354 Fenglin Lu, Shanghai, 200032 (China) |
| Abstract: | Dramatic rate enhancement of reductive elimination of Ar‐Pd‐C ] was observed in the presence of a phosphine/electron‐deficient olefin ligand. Through systematic kinetic investigations of the Negishi coupling of ethyl 2‐iodobenzoate with alkylzinc chlorides (see scheme), the rate constants for reductive elimination of Ar‐Pd‐C ] were determined to be greater than 0.3 s?1, which is about four or five orders of magnitude greater than values reported previously.  |
| Keywords: | cross‐coupling kinetics olefins palladium reductive elimination |