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Catalyzed Vinylogous Mukaiyama Aldol Reactions with Controlled Enantio‐ and Diastereoselectivities |
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| Authors: | Marcus Frings Iuliana Atodiresei Dr Jan Runsink Dr Gerhard Raabe Prof Dr Carsten Bolm Prof Dr |
| Institution: | Institut für Organische Chemie der RWTH Aachen University, Landoltweg 1, 52056 Aachen (Germany), Fax: (+49)?241‐8092391 |
| Abstract: | In control : A new catalytic vinylogous Mukaiyama aldol reaction provides products with high diastereo‐ and enantioselectivities (up to 99 % de and ee; see scheme). The relative and absolute stereochemistry of a representative product was rigorously assigned by NMR and CD spectroscopies (measured and calculated), X‐ray diffraction, and quantum‐chemical calculations.  |
| Keywords: | asymmetric catalysis copper diastereoselectivity enantioselectivity sulfoximines Mukaiyama aldol reaction |