|
|||||
|
|
Synthesis of Styrenes by Palladium(II)‐Catalyzed Vinylation of Arylboronic Acids and Aryltrifluoroborates by Using Vinyl Acetate |
|
| Authors: | Jonas Lindh Jonas Sävmarker Peter Nilsson Dr Per J R Sjöberg Dr Mats Larhed Prof |
| Institution: | 1. Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, Uppsala University, BMC, Box‐574, SE‐751 23 Uppsala (Sweden);2. Department of Physical and Analytical Chemistry, Uppsala University, BMC, Box‐599, SE‐751 23 Uppsala (Sweden) |
| Abstract: | One Heck of a reaction : Treatment of arylboronic acids or aryltrifluoroborates with vinyl acetate by using a palladium(II) catalyst gives the corresponding styrenes (see scheme). No palladium reoxidant is needed and the vinylation is performed under non‐inert conditions  |
| Keywords: | Heck reaction mass spectrometry mechanistic studies palladium styrene |