Diphenylprolinol Silyl Ether as a Catalyst in an Enantioselective,Catalytic Michael Reaction for the Formation of α,α‐Disubstituted α‐Amino Acid Derivatives
1. Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku‐ku, Tokyo 162‐8601 (Japan), Fax: (+81)?3‐5261‐4631;2. Research Institute for Science and Technology, Tokyo University of Science, Kagurazaka, Shinjuku‐ku, Tokyo 162‐8601 (Japan)
Abstract:
Direct and enantioselective : Diphenylprolinol silyl ether was found to catalyze the direct, asymmetric Michael reaction of 4‐substituted 2‐aryl‐2‐oxazoline‐5‐one and α,β‐unsaturated aldehydes, affording the chiral α,α‐disubstituted α‐amino acid derivatives with excellent enantioselectivity.
