Helical Chiral Pyridine N‐Oxides: A New Family of Asymmetric Catalysts |
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| Authors: | Jinshui Chen Dr. Norito Takenaka Prof. Dr. |
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| Affiliation: | Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, FL 33146‐0431 (USA), Fax: (+1)‐305‐284‐4571 |
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| Abstract: | Optically active chiral alkyl chlorides are valuable compounds because of their bioactivity and versatile synthetic utility. Accordingly, the ring opening of epoxides with a chloride nucleophile stands as an important goal in asymmetric catalysis. We describe herein recent advances in the design and development of chiral pyridine N‐oxide catalysts for the enantioselective synthesis of chlorohydrins. |
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| Keywords: | asymmetric catalysis atropisomerism chirality helical structures heterocycles |
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