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Synthesis of Spiroheterocycles by Palladium‐Catalyzed Domino Cycloisomerization/Cross‐Coupling of α‐Allenols and Baylis–Hillman Acetates |
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| Authors: | Benito Alcaide Prof Dr Pedro Almendros Dr Teresa Martínez del Campo Dipl‐Chem M Teresa Quirós Dipl‐Chem |
| Institution: | 1. Departamento de Química Orgánica I, Facultad de Química, Universidad Complutense de Madrid, 28040 Madrid (Spain), Fax: (+34)?91‐3944103;2. Instituto de Química Orgánica General, Consejo Superior de Investigaciones Científicas, CSIC, Juan de la Cierva 3, 28006 Madrid (Spain), Fax: (+34)?91‐5644853 |
| Abstract: | First insights into the reaction between a Baylis–Hillman adduct and an allene moiety have been obtained from the novel domino heterocyclization/cross‐coupling reaction of α‐allenols and Baylis–Hillman acetates, which furnishes (2,5‐dihydrofuran‐3‐yl)methyl]acrylate derivatives in moderate to good yields.  |
| Keywords: | allenes heterocycles palladium spiro compounds synthetic methods |