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Polymerase‐Catalysed Incorporation of Glucose Nucleotides into a DNA Duplex |
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| Authors: | Marleen Renders Mikhail Abramov Dr. Matheus Froeyen Piet Herdewijn Prof. Dr. |
| Affiliation: | Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000 Leuven (Belgium), Fax: (+32)?16‐337‐340 |
| Abstract: | Active but unselective : Nucleoside triphosphates possessing glucose moieties (such as those depicted) instead of the natural furanose rings are recognised by the active sites of polymerases. Polymerases therefore seem to be very unspecific in their recognition patterns.  |
| Keywords: | DNA structures enzyme catalysis hexose nucleotides nucleic acids polymerization |