1. State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000 (China), Fax: (+86)?931‐891‐2567;2. Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University (Hong Kong)
Abstract:
Zinc benefits : The first catalytic asymmetric phospha‐Michael addition of enones has been developed. Under mild reaction conditions, the γ‐oxo phosphonates could be obtained in high yields (up to 99 %) with excellent enantioselectivities (93–99 % ee; see scheme). The strategy makes the asymmetric synthesis of biologically important phosphonate compounds more accessible.
