| 碳糊电极阳极吸附伏安法测定环丙沙星 |
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| 引用本文： | 易兰花,王俊芬,黎拒难,高朋.碳糊电极阳极吸附伏安法测定环丙沙星[J].化学研究,2005,16(1):59-61,75. |
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| 作者姓名： | 易兰花 王俊芬 黎拒难 高朋 |
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| 作者单位： | 湘潭大学化学学院,湖南,湘潭,411105;湘潭市第二人民医院,湖南,湘潭,411102 |
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| 基金项目： | 中国科学院长春应用化学研究所电分析化学国家重点实验室基金项目(SKLEAC2003-5) . |
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| 摘 要： | 报道了用碳糊电极阳极吸附伏安法测定环丙沙星的新方法.在 0. 40mol/L的NH4Ac HAc(pH4. 30)缓冲液中,使用JP 303极谱分析仪,环丙沙星在碳糊电极 (CPE)上有一灵敏的吸附伏安氧化峰,峰电位为1. 12V(vs.SCE).该氧化峰的二阶导数峰电流与环丙沙星的浓度在 8. 0×10-9 ~8. 0×10-7 mol/L(富集 90s)范围内成良好的线性关系,相关系数为 0. 998 8,检出限为 4. 0×10-9 mol/L(S/N=3,富集 110s).探讨了环丙沙星在碳糊电极上的伏安性质和电极反应机理,并且成功应用于人体尿样中环丙沙星含量的测定.加入回收实验,回收率在95. 5%至 103. 9%之间.
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| 关 键 词： | 环丙沙星 阳极吸附伏安法 碳糊电极 |
| 文章编号： | 1008-1011(2005)01-0059-03 |
| 修稿时间： | 2004年9月6日 |
Anodic Adsorptive Voltammetric Determination of Ciprofloxacin with a Carbon Paste Electrode |
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| YI Lan-hua,WANG Jun-fen,LI Ju-nan,GAO Peng.Anodic Adsorptive Voltammetric Determination of Ciprofloxacin with a Carbon Paste Electrode[J].Chemical Research,2005,16(1):59-61,75. |
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| Authors: | YI Lan-hua WANG Jun-fen LI Ju-nan GAO Peng |
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| Institution: | YI Lan-hua~1,WANG Jun-fen~2,LI Ju-nan~ |
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| Abstract: | A highly selective and rapid new anodic adsorptive voltammetric method has been developed for the determination of ultra trace amount of ciprofloxacin with a carbon paste electrode (CPE). Ciprofloxacin is adsorbed on the surface of CPE, yielding one oxidation peak at 1.12 V (vs.SCE) in 0.40 mol/L NH_(4)Ac-HAc buffer solution (pH 4.30) by using JP-303 polarographic analyser. The relationship between the peak current and ciprofloxacin concentration is linear in the range of 8.0 10~(-9)～8.0×10~(-7) mol/L with a correlation coefficients of 0.998 8. The detection limit is 4.0×10~(-9) mol/L (S/N=3) for 110 s accumulation. The electrode reaction mechanism of ciprofloxacin was investigated. The proposed method was applied to determine trace ciprofloxacin in the urine samples with satisfactory results. |
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| Keywords: | ciprofloxacin adsorptive anodic-stripping voltammetry carbon paste electrode |
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