Analysis of unknown compounds in gentamicin bulk samples with liquid chromatography coupled with ion trap mass spectrometry |
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| Authors: | Li Bo Adams Erwin Van Schepdael Ann Hoogmartens Jos |
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| Institution: | Katholieke Universiteit Leuven, Faculteit Farmaceutische Wetenschappen, Laboratorium voor Farmaceutische Chemie en Analyse van Geneesmiddelen, O&N2, PB 923, Herestraat 49, B-3000 Leuven, Belgium. |
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| Abstract: | Six unknown compounds present in bulk gentamicin samples have been identified by ion-pairing reversed-phase liquid chromatography coupled with ion trap mass spectrometry. The structures of these unknown compounds were deduced by comparison of their fragmentation patterns with those of the available related substances and gentamicin reference substances. Seven other unknown components were partially identified. |
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