An expedient synthesis of the repeating unit of the acidic polysaccharide of the bacteriolytic complex of lysoamidase |
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| Authors: | Litjens Remy E J N den Heeten René Timmer Mattie S M Overkleeft Herman S van der Marel Gijsbert A |
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| Institution: | Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands. |
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| Abstract: | The first synthesis of the trisaccharide repeating unit of the acidic polysaccharide of the bacteriolytic complex of lysoamidase is presented. The construction is based on a linear glycosylation strategy that starts from the reducing end and employs thio- and selenoglycosides in a highly stereoselective manner by a single set of activation conditions. The thus-formed trisaccharide is selectively deprotected and oxidised, after which a final deprotection step furnishes the desired repeating unit. |
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| Keywords: | carbohydrates glycosylation lysoamidase oligosaccharides uronic acids |
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