Synthesis of microcin SF608 |
| |
Authors: | Valls Nativitat Vallribera Mercè López-Canet Meritxell Bonjoch Josep |
| |
Institution: | Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028-Barcelona, Spain. |
| |
Abstract: | The first total synthesis of aquatic peptide microcin SF608 is described. Coupling of L-Hpla with the dipeptide L-Phe-L-Choi followed by coupling with agmatine and a deprotection step gave microcin SF608. In addition, the levorotatory character of L-Hpla (5) was thoroughly established, and the conformational analysis of L-Choi containing peptides 1 and 8-10 was performed using NMR spectroscopy to examine the cis-trans isomer equilibrium of the L-Phe-L-Choi amide bond. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|