| 通过三乙基铝促进的a-羟基环氧化合物的重排还原反应合成Madindoline母核片断——全取代环戊烯二酮单元 |
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| 引用本文： | 高栓虎,贾彦兴,赵学智,涂永强.通过三乙基铝促进的a-羟基环氧化合物的重排还原反应合成Madindoline母核片断——全取代环戊烯二酮单元[J].中国化学,2006,24(5):595-597. |
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| 作者姓名： | 高栓虎 贾彦兴 赵学智 涂永强 |
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| 作者单位： | State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China （Nos, 29525205, 30271488, 20021001 and 203900501 ）. |
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| 摘 要： | The fully substituted cyclopentenedione core of madindoline A （1） and B （2） as potent and selective inhibitor of IL-6 has been synthesized efficiently. The quaternary carbon center C-2＇ was constructed on the basis of a newly developed AIEt3-promoted tandem reductive rearrangement of α-hydroxy epoxides.
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| 关 键 词： | 环戊烯二酮 重排 α-羟基环氧化物 总合成 串联反应 |
| 收稿时间： | 2005-09-21 |
| 修稿时间： | 2005-09-212005-11-23 |
A Novel Strategy for the Key Fully Substituted Cyclopentenedione Moiety of Madindolines via AlEt3‐promoted Tandem Reductive Rearrangement of α‐Hydroxy Epoxides |
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| GAO Shuan-Hu,JIA Yan-Xing,ZHAO Xue-Zhi, TU Yong-Qiang.A Novel Strategy for the Key Fully Substituted Cyclopentenedione Moiety of Madindolines via AlEt3‐promoted Tandem Reductive Rearrangement of α‐Hydroxy Epoxides[J].Chinese Journal of Chemistry,2006,24(5):595-597. |
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| Authors: | GAO Shuan-Hu JIA Yan-Xing ZHAO Xue-Zhi TU Yong-Qiang |
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| Abstract: | The fully substituted cyclopentenedione core of madindoline A ( 1 ) and B ( 2 ) as potent and selective inhibitor of IL‐6 has been synthesized efficiently. The quaternary carbon center C‐2′ was constructed on the basis of a newly developed AlEt3‐promoted tandem reductive rearrangement of α‐hydroxy epoxides. |
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| Keywords: | madindoline total synthesis tandem reaction quaternary carbon epoxide rearrangement |
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