Thermochemical analysis of intermolecular interactions between <Emphasis Type="Italic">N</Emphasis>-acetylglycine and polyols in aqueous solutions

The integral enthalpies of dissolution Δ_sol H _m for N-acetylglycine in aqueous solutions of glycerol, ethylene glycol and 1,2-propylene glycol are measured via solution calorimetry. The standard enthalpies of dissolution (Δ_sol Н ⁰) and transfer (Δ_tr Н ⁰) for N-acetylglycine from water to aqueous solutions of polyhydric alcohols are calculated from experimental data. Positive values of enthalpy coefficients of pair interactions h _xy for amino acids and polyol molecules are calculated using the McMillan–Mayer theory. The results are discussed using an approach for evaluating different types of interactions in ternary systems and the effect the structural features of interacting biomolecules have on the thermochemical characteristics of N-acetylglycine dissolution.