Lewis acid-mediated radical cyclization: stereocontrol in cascade radical addition-cyclization-trapping reactions |
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| Authors: | Miyabe Hideto Asada Ryuta Takemoto Yoshiji |
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| Affiliation: | Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. miyabe@huhs.ac.jp |
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| Abstract: | ![]()
An efficient approach for achieving radical cyclizations by using hydroxamate ester as a coordination tether with Lewis acid was studied. The chiral Lewis acid-mediated cascade radical addition-cyclization-trapping reaction proceeded smoothly with good enantio- and diastereoselectivities, providing various chiral γ-lactams. |
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