|
|||||
|
|
Silanediols: A New Class of Potent Protease Inhibitors |
|
| Authors: | Scott McN Sieburth Thomas Nittoli Alfred M Mutahi Luxuan Guo |
| Abstract: | Transition state analogues of the peptide hydrolysis intermediate can take the form of complex silanediols such as 1 , which inhibits angiotensin-converting enzyme (ACE) at nanomolar concentrations. In contrast, earlier investigation of enzyme inhibition with simple silanediols and silanetriols showed them to be inactive. |
| Keywords: | Angiotensin-converting enzyme Enzyme inhibitors Peptidomimetics Silanols Structure– activity relationships |