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Desulfation and rearrangement of tigemonam to an isoxazolidin-5-one and the synthesis of the rearrangement product |
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| Authors: | Janak Singh Thomas P Kissick Rita Fox Octavian Kocy Richard H Mueller |
| Abstract: | The β-lactam antibiotic Tigemonam 2 undergoes desulfation to the N-hydroxyazetidinone 4 , which rearranges to the isoxazolidin-5-one 6 . The structure of the rearrangement product 6 was confirmed by synthesis. |
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