First total synthesis of A(2) isoprostane |
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| Authors: | Zanoni Giuseppe Porta Alessio Vidari Giovanni |
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| Institution: | Department of Organic Chemistry, University of Pavia, Viale Taramelli, 10, 27100, Italy. gzanoni@unipv.it |
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| Abstract: | A stereoselective Julia-Lythgoe olefination has allowed the first total synthesis of A(2) isoprostane (1), a recently discovered member of the growing isoprostane family. This elusive compound opens up numerous new avenues for the molecular biology of cyclopentenone prostaglandins, which are endowed of intriguing biological effects such as antitumor, antiinflammatory, and antiviral activities. |
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