| 新型3-取代-6-(4-氯苯基)-7-(1H-1,2,4-三唑-1-基)-1',2',4'-三唑[3,4-b]-1",3",4"-噻二嗪衍生物的合成及抗菌活性 |
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| 引用本文： | 惠新平,张艳,许鹏飞,王勤,张琪,张自义.新型3-取代-6-(4-氯苯基)-7-(1H-1,2,4-三唑-1-基)-1',2',4'-三唑[3,4-b]-1",3",4"-噻二嗪衍生物的合成及抗菌活性[J].有机化学,2005,25(6). |
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| 作者姓名： | 惠新平 张艳 许鹏飞 王勤 张琪 张自义 |
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| 作者单位： | 1. 兰州大学功能有机分子化学国家重点实验室,化学化工学院,兰州,730000
2. 兰州大学生命科学学院,兰州,730000 |
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| 摘 要： | 通过3-取代-4-氨基-5-巯基-1,2,4-三唑(3a～3m)和2-溴-2-(1H–1,2,4-三唑-1-基)-4′-氯代苯乙酮(2)的缩合反应,合成了13个新型3-取代-6-(4-氯苯基)-7-(1H-1,2,4-三唑-1-基)-1',2',4'-三唑3,4-b]-1",3",4"-噻二嗪衍生物4a～4m.化合物结构经元素分析,1HNMR,IR和MS进行了表征.抗菌试验表明所合成的化合物对细菌表现出中等程度的抑制活性.
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| 关 键 词： | 1H-1 2 4-三唑 1 2 4-三唑[3 4-b]-1' 3' 4'-噻二嗪 抗菌活性 |
Synthesis and Antibacterial Activities of Novel 4-Substituted-6-(4-chlorophenyl)-7-(1H-1,2,4-triazol-1-yl)-1',2',4'-triazolo[3,4-b]-1",3",4"-thiadiazines |
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| HUI Xin-Ping,ZHANG,Yan,XU Peng-Fei,WANG Qin,ZHANG Qi,ZHANG Zi-Yi.Synthesis and Antibacterial Activities of Novel 4-Substituted-6-(4-chlorophenyl)-7-(1H-1,2,4-triazol-1-yl)-1',2',4'-triazolo[3,4-b]-1",3",4"-thiadiazines[J].Chinese Journal of Organic Chemistry,2005,25(6). |
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| Authors: | HUI Xin-Ping ZHANG Yan XU Peng-Fei WANG Qin ZHANG Qi ZHANG Zi-Yi |
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| Institution: | HUI,Xin-Ping*,a ZHANG,Yana XU,Peng-Fei*,a WANG,Qinb ZHANG,Qib ZHANG,Zi-Yia |
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| Abstract: | |
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| Keywords: | 1H-1 2 4-triazole 1 2 4-triazolo[3 4-b]-1' 3' 4'-thiadiazine antibacterial activity |
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