A high performance liquid chromatographic system for the analysis of tetracycline drug standards, analogs, degradation products and other impurities |
| |
Authors: | G D Mack R B Ashworth |
| |
Abstract: | This paper describes the high performance liquid chromatographic (HPLC) analysis of eight parent tetracycline standards: tetracycline, chlortetracycline, rolitetracycline, oxitetracycline, minocycline, doxycycline, democlocycline, methacycline; and three tetracycline epimers: epitetracycline, epianhydrotetracycline, and anhydrotetracycline. The HPLC system employs an octadecylsilane reverse phase column and an isopropanol-diethanolamine-phosphate-ammonium EDTA-water mobile phase. This system produced at least partial resolution of all eight parent compounds and many of their degradation products. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|