| O-羧甲基壳聚糖稀土配合物的抑菌活性及与DNA的相互作用 |
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| 引用本文： | 李小芳,冯小强,杨声.O-羧甲基壳聚糖稀土配合物的抑菌活性及与DNA的相互作用[J].分析科学学报,2012,28(1):113-115. |
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| 作者姓名： | 李小芳 冯小强 杨声 |
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| 作者单位： | 1. 天水师范学院生命科学与化学学院,甘肃天水,741001
2. 定西师范高等专科学校,甘肃定西,743000 |
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| 基金项目： | 天水师院物理无机化学重点学科基金，天水师院"青蓝"人才工程资助项目，天水师院中青年教师科研资助项目 |
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| 摘 要： | 用体外抑菌法研究了O-羧甲基壳聚糖镧、O-羧甲基壳聚糖钕配合物对大肠杆菌(E.coli)、金黄色葡萄球菌(St.aureus)、阴沟肠杆菌(E.cloacae)、枯草芽孢杆菌(B.subtilis)、粪肠杆菌(E.faecalis)和肺炎克罗伯杆菌(S.pneumoniae)的抑菌活性。采用紫外光谱研究了两种O-羧甲基壳聚糖稀土配合物与小牛胸腺DNA的相互作用。结果表明:O-羧甲基壳聚糖稀土配合物均有抑菌活性,且O-羧甲基壳聚糖稀土配合物与DNA以静电作用为主,能使DNA双螺旋结构破坏。
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| 关 键 词： | O-羧甲基壳聚糖 稀土 配合物 抑菌 小牛胸腺DNA |
Antibacterial Activity of Rare Earth Complexes of O-Carboxymethyl Chitosan and Interaction with DNA |
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| LI Xiao-fang
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FENG Xiao-qiang
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YANG Sheng.Antibacterial Activity of Rare Earth Complexes of O-Carboxymethyl Chitosan and Interaction with DNA[J].Journal of Analytical Science,2012,28(1):113-115. |
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| Authors: | LI Xiao-fang FENG Xiao-qiang YANG Sheng |
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| Institution: | 1.College of Life Sciences and Chemistry,Tianshui Normal University,Tianshui 741001; 2.Dingxi Teachers’ College,Dingxi 743000) |
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| Abstract: | The antibacterial activity of rare earth complexes of O-carboxymethyl chitosan against E.coli,St.aureus,E.cloacae,B.subtilis,E.faecalis and S.pneumoniae was investigated in vitro.The interaction of rare earth complexes of O-carboxymethyl chitosan with calf thymus DNA was studied via UV spectroscopy.Results showed that the rare earth complexes of O-carboxymethyl chitosan had antibacterial activity,and could damage the double helix structure of calf thymus DNA. |
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| Keywords: | O-carboxymethyl chitosan Rare earth Complex Antibacterial activity Calf thymus DNA |
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