| Approach to 2′-(Dialkylamino)-1-alkyl-4′H-spiro[indoline-3,5′-oxazole]-2,4′-diones and 1,3-Oxazin-4-ones via Cyclization of Vilsmeier Salts withα-Hydroxy andβ-Carbonyl Amides |
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| 作者姓名： | DAI Jianan LIU Bengen WEI Zhonglin CAO Jungang LIANG Dapeng DUAN Haifeng LIN Yingjie |
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| 作者单位： | Department of Organic Chemistry |
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| 基金项目： | the National Natural Science Foundation of China |
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| 摘 要： | A straiglitforward and efficient synthetic method of 2′-(dialkylammo)-l-alkyl-4′H-spiroindoline-3,5′-oxazole]-2,4′-diones and 2-(dialkylamino)-5,6-dihydro-4H-naphtho2,1-e]1,3]oxazin-4-one-derivatives have been developed from a-hydroxy andβ-carbonyl amides and various Vilsmeier salts.A wide range of heterocyclic compounds were obtained in excellent yields(up to 97%),which will provide promising candidates lor chemical biology and drug discovery.
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| 关 键 词： | SPIROOXINDOLE unit 2-Oxazolin-4-ones CORE STRUCTURE 3-Oxazin-4-ones CORE STRUCTURE |
| 收稿时间： | 2018-09-25 |
Approach to 2'-(Dialkylamino)-1-alkyl-4'H-spiro[indoline-3,5'-oxazole]-2,4'-diones and 1,3-Oxazin-4-ones via Cyclization of Vilsmeier Salts with α-Hydroxy and β-Carbonyl Amides |
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| DAI Jianan,LIU Bengen,WEI Zhonglin,CAO Jungang,LIANG Dapeng,DUAN Haifeng,LIN Yingjie.Approach to 2'-(Dialkylamino)-1-alkyl-4'H-spiro[indoline-3,5'-oxazole]-2,4'-diones and 1,3-Oxazin-4-ones via Cyclization of Vilsmeier Salts with α-Hydroxy and β-Carbonyl Amides[J].Chemical Research in Chinese University,2019,35(2):216-220. |
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| Authors: | DAI Jianan LIU Bengen WEI Zhonglin CAO Jungang LIANG Dapeng DUAN Haifeng LIN Yingjie |
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| Institution: | Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China |
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| Abstract: | A straightforward and efficient synthetic method of 2'-(dialkylamino)-1-alkyl-4'H-spiroindoline-3,5'-oxazole]-2,4'-diones and 2-(dialkylamino)-5,6-dihydro-4H-naphtho2,1-e] 1,3]oxazin-4-one derivatives have been developed from α-hydroxy and β-carbonyl amides and various Vilsmeier salts. A wide range of heterocyclic compounds were obtained in excellent yields(up to 97%), which will provide promising candidates for chemical biology and drug discovery. |
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| Keywords: | Spirooxindole unit 2-Oxazolin-4-ones core structure 3-Oxazin-4-ones core structure |
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