| Abstract: | Abstract A new cyproheptadine hydrochloride (CHDHC1) ion selective F VC membrane electrode based on the ion-pair complex of CHDHC1 with sodium tetraphenylborate was prepared and its performance characteristics were studied. The electrode exhibited a Jinear response with a good Nernstian slope over a relatively wide range of concentration. Up to 21 days of continuous soaking, the calibration graph slope was constant at 57.1 mV/concentration decade, at 25°C, then it decreased as the time of soaking increases reaching 32.9 mV/decade after 37 days. The change in pH did not affect the electrode performance within the range 2–6. The standard electrode potentials were determined at different temperatures and used to calculate the isothermal coefficient of electrode. The electrode showed very good selectivity for CHDHC1 with respect to a large number of inorganic and organic cations. The standard addition method and potentiometric titration were used to determine (CHDHC1) in pure solution and in a. pharmaceutical preparation. |
