Phosphomolybdic acid as a reagent for the spectrophotometric determination of certain phenothiazine derivatives of pharmaceutical products |
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Authors: | Stan M Dorneanu V Ghimicescu G |
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Institution: | Faculty of Pharmacy, Str. Universitatii 16, Iasi, Romania. |
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Abstract: | Phosphomolybdic acid is used as reagent for colorimetric determination of phenothiazine derivatives in various pharmaceutical products. The reagent oxidizes the derivative to a cationic free radical, with which it then forms a coloured salt. The method is simple and rapid. A preliminary extraction is necessary if certain reductants (sulphite or ascorbic acid) are present as stabilizers of the pharmaceuticals, as otherwise they reduce the reagent to phosphomolybdenum blue. |
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