Introduction of a tritium label into nucleoside analogs modified in their carbohydrate residues |
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| Authors: | L A Yakovleva G P Akulov A I Nagorskii N A Patokina Yu L Kaminskii R Z Zhuk |
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| Institution: | (1) V. G. Khlopin Radium Institute, Leningrad;(2) Institute of Organic Synthesis, Latvian SSR Academy of Sciences, Riga |
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| Abstract: | The synthesis has been effected of arabinofuranosylcytosine, -uracil, and -adenine, and of ftorafur tegafur] and acyclovir, all containing a tritium label. The introduction of tritium was effected by reductive dehalogenation and desulfuration and also by the isotope exchange reaction.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 95–99, January, 1988. |
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