New stereoselective reaction of methylglyoxal with 2-aminopyridine and adenine derivatives: formation of imino acid-nucleic base derivatives in water under mild conditions |
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| Authors: | Routaboul Christel Dumas Lionel Gautier-Luneau Isabelle Vergne Jacques Maurel Marie-Christine Décout Jean-Luc |
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| Institution: | Laboratoire de Chimie Bio-organique, Département de Pharmacochimie Moléculaire, UMR 5063 CNRS/Université Joseph Fourier-Grenoble I, Domaine de la Merci, F-38706 La Tronche, France. |
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| Abstract: | A remarkable stereoselective reaction of methylglyoxal with 2-aminopyridine, the nucleic base adenine and adenine nucleosides leads in good yield to heterocycles of a new family in water under mild conditions and should be of interest in the understanding of the biological effects of methylglyoxal which is toxic, mutagenic and involved in diabetic complications. |
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