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Metal- and acid-free,TBN-mediated direct CH nitration of arenes
Authors:Guangqiang Xu  Li Zhou  Chengdong Lv  Mo Xian  Qinggang Wang
Institution:1. Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China;2. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
Abstract:A metal-free, acid-free, direct and eco-friendly nitration methodology has been developed. A tert-butyl nitrite efficiently promotes the direct C />H nitration of electron-rich arenes with good to excellent yields and regioselectivities. The practical utility of this protocol has been demonstrated in gram-scale nitration of crown ether and mono nitration of Sesamin. A plausible free radical mechanism is proposed based on detailed experimental observations.</td>
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Keywords:Corresponding authors    Metal-free  Acid-free  Nitration  Electron-rich arenes
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