Electrospun non-woven nanofibrous hybrid mats based on chitosan and PLA for wound-dressing applications |
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Authors: | Ignatova Milena Manolova Nevena Markova Nadya Rashkov Iliya |
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Institution: | Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev 103A, 1113 Sofia, Bulgaria. |
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Abstract: | Continuous defect-free nanofibers containing chitosan (Ch) or quaternized chitosan (QCh) were successfully prepared by one-step electrospinning of Ch or QCh solutions mixed with poly(L-lactide)-co-(D,L-lactide)] in common solvent. XPS revealed the surface chemical composition of the bicomponent electrospun mats. Crosslinked Ch- and QCh-containing nanofibers exhibited higher kill rates against bacteria S. aureus and E. coli than the corresponding solvent-cast films. SEM observations showed that hybrid mats were very effective in suppressing the adhesion of pathogenic bacteria S. aureus. The hybrid nanofibers are promising for wound-healing applications. |
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Keywords: | antibacterial activity chitosan electrospinning nanotechnology poly[(L‐lactide)‐co‐(D L‐lactide)] wound healing |
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