A one-pot synthesis of 2,3-dihydro-1H-pyrrolo[3,2-c]quinolines |
| |
| Authors: | Miroslaw J. Tomaszewski |
| |
| Affiliation: | Department of Medicinal Chemistry, AstraZeneca R&D Montreal, 7171 Frederick-Banting, Saint-Laurent, Quebec, Canada H4S 1Z9 |
| |
| Abstract: | A one-pot synthesis of the 2,3-dihydro-1H-pyrrolo[3,2-c]quinoline core from substituted 2-iodoanilines and 2,3-dihydro-1H-pyrrole was achieved using 10 mol % Pd(PPh3)4, and K2CO3 in 1,4-dioxane at 170 °C for 1 h in a microwave oven. This reaction can be carried out on a gram scale. The proposed mechanism involves a Heck-coupling reaction followed by intra-molecular Schiff base formation and double bond migration. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
