Direct conversion of benzylic and allylic alcohols to phosphonates |
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Authors: | Barney Rocky J Richardson Rebekah M Wiemer David F |
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Institution: | Department of Chemistry, University of Iowa, Iowa City, Iowa 52242-1294, United States. |
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Abstract: | Benzyl phosphonate esters often serve as reagents in Horner-Wadsworth-Emmons reactions. In most cases, they can be prepared from benzylic alcohols via formation of the corresponding halide followed by an Arbuzov reaction. To identify a more direct synthesis of phosphonate esters, we have developed a one-flask procedure for conversion of benzylic and allylic alcohols to the corresponding phosphonates through treatment with triethyl phosphite and ZnI(2). |
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