The dipole approach in the lon-interaction chromatography of zwitterions— Use of a potential approximation to obtain a simplified retention equation |
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Authors: | T Cecchi P Cecchi |
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Institution: | (1) Dipartimento di Scienze Chimiche, Università degli Studi di Camerino, Via S Agostino 1, 62032 Camerino, (MC), Italy;(2) Dipartimento ABAC, Università della Tuscia, Via S. C. De Lellis, 01100 Viterbo, Italy;(3) Present address: ITIS Montani, Via Montani 7, 63023 Fermo (AP), Italy |
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Abstract: | Summary In ion-interaction chromatography (IIC) the zwitterionic analyte is believed to interact with the stationary phase potential
as a result of its electrical dipole, and to compete with the ion-interaction reagent (IIR) for available inner layer sites.
The most reliable set of literature data relating to the retention behavior of zwitterions in IIC has been used for successful
testing of a high surface-potential approximation which enables the fitting of retention data without detailed information
about the physical and chemical properties of the mobile phase. This approach can explain quantitatively, very simply, the
retention behavior of zwitterions in IIC. |
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Keywords: | Column liquid chromatography Ion-interaction chromatography Zwitterion analyte Retention equation High surface potential approximation |
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