| 4-氨基丁醇的高效合成方法 |
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| 引用本文： | 赵辉,苏多猛,刘玉军,王凯.4-氨基丁醇的高效合成方法[J].化学通报,2016,79(5):453-454. |
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| 作者姓名： | 赵辉 苏多猛 刘玉军 王凯 |
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| 作者单位： | 安徽省科学技术研究院,安徽省应用技术研究院,安徽省科学技术研究院,安徽省应用技术研究院 |
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| 基金项目： | 安徽省国际科技合作计划项目（1403062019,1303063027），安徽省第六批“115”产业创新团队“植物源农业关键技术产业创新团队” |
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| 摘 要： | 以2, 3-二氢呋喃为原料，先用酸性水溶液处理，得到的粗品再直接与盐酸羟胺发生反应，得到4-羟基丁基肟，再与还原试剂发生还原反应，最终高效得到4-氨基丁醇产品。此合成方法步骤短且易操作，产率高，可用于大量生产。
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| 关 键 词： | 4-氨基丁醇 肟 还原 合成 |
| 收稿时间： | 2015/11/26 0:00:00 |
| 修稿时间： | 2015/12/9 0:00:00 |
Efficient Synthesis of 4-aminobutan-1-ol |
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| Zhao Hui,Su Duomeng,Liu Yujun and Wang Kai.Efficient Synthesis of 4-aminobutan-1-ol[J].Chemistry,2016,79(5):453-454. |
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| Authors: | Zhao Hui Su Duomeng Liu Yujun and Wang Kai |
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| Institution: | Anhui Academy of Science and Technology,Hefei,Anhui,Anhui Academy of Application Technology,Hefei,Anhui,Anhui Academy of Science and Technology,Hefei,Anhui,Anhui Academy of Application Technology,Hefei,Anhui |
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| Abstract: | The reaction of the crude product, obtained by acidifying the starting material 2,3-dihydrofuran, with hydroxylamine hydrochloride afforded 4-hydroxybutanal oxime, which was reduced by reductive reagent to give the final product 4-aminobutan-1-ol. This method was not only simple but easy to operate, and the yield was high, which could be used for mass production. |
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| Keywords: | 4-aminobutan-1-ol oxime reduction synthesis |
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