| 苯驳三氮唑胺烷基化及N一取代芳胺的简便合成 |
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| 引用本文： | 王瑾,杜少斌.苯驳三氮唑胺烷基化及N一取代芳胺的简便合成[J].浙江大学学报(理学版),1992,19(4):432-436. |
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| 作者姓名： | 王瑾 杜少斌 |
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| 作者单位： | 杭州大学化学系
(王瑾，杜少斌，周洵钧)，杭州大学化学系(范伟强) |
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| 摘 要： | 苯骄三氮哇、胺和甲醛在乙晾溶液中发生Mannich反应，生成胺烷基化的苯骄三氮哇衍生物，胺可以是芳香或杂环一级、二级胺，产率很高.上述反应生成的苯骄三氮哇衍生物在硼氢化钠作用下或与格氏试剂反应生成二级或三级芳胺，该法操作简便，条件温和，无副反应.
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| 关 键 词： | 苯骈三氮唑 胺烷基化 N－取代芳胺 |
The Aminoalkylation of Benzotriazole and Synthesis of N-Substituted Arylamines |
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| Wang Jin,Du Shaobin,Zhou Xunjun,Fan Weiqiang.The Aminoalkylation of Benzotriazole and Synthesis of N-Substituted Arylamines[J].Journal of Zhejiang University(Sciences Edition),1992,19(4):432-436. |
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| Authors: | Wang Jin Du Shaobin Zhou Xunjun Fan Weiqiang |
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| Institution: | Department of Chemistry |
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| Abstract: | The aminoalkylation of benzotriazole derivatives was obtained from benzotriazole, amines and formaldehyde in alcohol by Mannich type condensation. This method gives good yields. Furthermore, all derivatives could be reduced by NaBH4 and reacted with Grignard agents in THF to give secondary or tertiary amines, they gave mild reaction conditions and high yields. |
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| Keywords: | benzotriazole aminoalkylation N-substituted arylamine mannich type condensation |
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