Chemical Constituents from Alafia Barteri Oliv. Leaves with Cytotoxic Activity |
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| Authors: | Olapeju O Aiyelaagbe Arvind S Negi Abdulmumeen A Hamid Suaib Luqman Sathish B Kumar Fatima Kaneez |
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| Institution: | 1. Department of Chemistry, University of Ibadan, Oyo State, Nigeria;2. Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, India;3. Department of Chemistry, University of Ilorin, Kwara State, Nigeria, Tel: +2347035931646Department of Chemistry, University of Ilorin, Kwara State, Nigeria, Tel: +2347035931646 |
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| Abstract: | Methanol extract of Alafia barteri leaves showed cytotoxic activity on leukaemia carcinoma K562, and hepatic liver cancer cells WRL (IC50 values 193.1 and 225.0 μM respectively). Isolation of the extract gave ursane triterpenoid, 28‐acety‐urs‐5,20‐dien‐2β,3β,24α‐triol, 1 , together with undecanol, 2 , stigmasterol, 3 and octadecanoic acid, 4 . The structures of these compounds were identified by spectroscopic analysis, including MS, 1D and 2D NMR, and supported with literature data. Compound 1 exhibited cytotoxic activity against K‐562 at 50 and 100 μM concentrations with IC50 74.22 μM, while compounds 2 , 3 and 4 showed low inhibition of WRL, MCF‐7 and COLO cell lines. |
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| Keywords: | Alafia barteri Oliv Cytotoxic activity Traditional medicine 28‐acety‐urs‐5 20‐dien‐2β 3β 24α ‐triol Stigmasterol Octadecanoic acid |
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