Two New Cytotoxic Spirostane‐Steroidal Saponins from the Roots of Bletilla striata |
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| Authors: | Jong Eel Park Kyeong Wan Woo Sang Un Choi Je Hyun Lee Kang Ro Lee |
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| Institution: | 1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 440‐746, Korea, (phone: +82‐31‐2907710;2. fax: +82‐31‐2907730);3. Korea Research Institute of Chemical Technology, Teajeon 305‐600, Korea;4. Department of Korean Medicine, Dongguk University, Gyeongju‐si, Gyeongbuk 780‐714, Korea |
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| Abstract: | Two new spirostane‐steroidal saponins, bletilnoside A ( 1 ) and bletilnoside B ( 2 ), together with five known compounds, 3 – 7 , were isolated from the roots of Bletilla striata (Thunb .) Reichb . F. The structures of the new compounds were determined based on their 1D‐ and 2D‐NMR spectral data. The isolated compounds 1 – 7 were tested for cytotoxicity against four human tumor cells (A549, SK‐OV‐3, SK‐MEL‐2, and HCT15) in vitro using a sulforhodamin B bioassay, and compounds 1, 2 , and 5 showed significant cytotoxicities against all tested tumor cell lines with IC50 values ranging from 3.98±0.16 to 12.10±0.40 μM . |
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| Keywords: | Bletilla striata Saponins Spirostane Steroids Cytotoxic activity |
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