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An Unexpected Role of Carbon Disulfide: A New and Efficient Method for the Synthesis of 2‐Substituted Benzimidazoles |
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| Authors: | John A Gladysz Hamid Reza?Safaei Sara Nouri |
| Institution: | 1. Department of Chemistry, Texas A&M University, P.O. Box 30012, College Station, Texas 77842‐3012, USA;2. Department of Applied Chemistry, Faculty of Science, Shiraz Branch, Islamic Azad University, P.O. Box 71993‐5, Shiraz, Iran (phone: +98‐71‐36402715;3. fax: +98‐71‐36412488) |
| Abstract: | A new and efficient methodology for the synthesis of 2‐substituted benzimidazoles is described. In this procedure, CS2 unexpectedly facilitated the cyclization reaction between benzene‐1,2‐diamine and benzenecarbaldehydes in CH2Cl2 at room temperature. The reactions occur under mild conditions require simpler equipment and easier workup procedures. |
| Keywords: | Benzimidazoles Cyclization reactions Carbon disulfide Dithiocarbamic acid |