Two New Dammarane‐Type Triterpenoid Saponins from Gynostemma pentaphyllum |
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| Authors: | Lin Shi De‐Hong Tan Yun‐En Liu Ming‐Xiao Hou Yu‐Qing Zhao |
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| Affiliation: | 1. College of Food Science, Shenyang Agricultural University, Dongling Road 120, Shenyang 110866, P.?R. China (phone: +86‐24‐88487161;2. fax: +86‐24‐88487161);3. Laboratory of Rescue Center of Severe Wound and Trauma, PLA, General Hospital of Shenyang Military Command, Wenhua Road 83, Shenyang 110016, P.?R. China;4. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, P.?R. China |
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| Abstract: | Two new dammarane‐type triterpenoid saponins were isolated from the EtOH extract of Gynostemma pentaphyllum (Thunb .) Makino . Their structural elucidations were accomplished mainly on the basis of the interpretation of spectroscopic data, such as IR, NMR, and HR‐TOF‐MS. Their liver fibrosis inhibitory activities were evaluated against hepatic stellate cells using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) assay. Thus, G. pentaphyllum can be used as ingredient for ancillary drugs or functional food. |
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| Keywords: | Gynostemma pentaphyllum Saponins Triterpenoids Dammarane Liver fibrosis inhibitory activity Hepatic stellate cells (HSCs) |
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