Synthesis of Z‐Protected Aib‐ and Phe(2Me)‐Containing Pentapeptides and Their Crystal Structures |
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| Authors: | Anthony Linden Heinz Heimgartner |
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| Institution: | 1. Institut für Chemie der Universit?t Zürich, Winterthurerstrasse 190, CH‐8057 Zürich, (phone: +41?44?635?4282;2. fax: +41?44?635?6812) |
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| Abstract: | A series of pentapeptide derivatives containing α,α‐disubstituted α‐amino acids have been prepared by a combination of the ‘azirine/oxazolone method’ and segment condensations. X‐Ray crystal‐structure determinations of the molecular structures confirmed the presence of helical conformations stabilized by β‐turns of type III or III′. Pentapeptides containing (R)‐Phe(2Me) form a right‐handed helix, whereas those containing (S)‐Phe(2Me) adopt a left‐handed helical structure. |
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| Keywords: | Peptides ‘ Azirine/oxazolone method’ α ‐Amino acids α α ‐disubstituted X‐Ray crystallography |
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