氢键介质的芳酰胺折叠体:从构象控制到功能演化

根据芳环上酰胺和氢键受体位置的不同,氢键介质的芳酰胺和酰肼折叠体可以产生折叠、螺旋、"之"字型、直线型及其他扩展型的构象.由于氢键具有较高的稳定性及芳酰胺固有的平面性特征,这一系列的芳酰胺寡聚体拥有较高的可预测的构象.芳酰胺骨架本身可以通过简单的酰胺键偶合反应构筑,而不同的官能团也可以选择性地引入到特定的骨架内部或其侧...

Hydrogen Bonded Arylamide Foldamers:from Conformational Controlto Functional Evolution

Hydrogen bonded aryl amide and hydrazide foldamers may adopt folded or helical, zigzag, straight or other extended conformations, depending on the positions of the amides and hydrogen bonding acceptors on the aromatic rings. Because of the relatively high strength of hydrogen bonding and the intrinsic planarity of the arylamide units, this family of amide oligomers usually possesses highly predictable conformations. The frameworks themselves can be conveniently constructed via simple amide coupling reactions, while discrete functional groups can be introduced to the frameworks or appended side chains at required positions. Thus, in the past few years, we have focused on their applications in designing new molecular tweezers, for generating welldefined and functional supramolecular systems, including organogels, vesicles and liquid crystals, and for directing the formation of complicated macrocyclic systems. More recently, we have found that hydrogen bonding-driven folded segments can also be incorporated into polymers to reversibly tune their mechanical property through the breaking and recovering of the intramolecular hydrogen bonds. This Mini Account summarizes our recent efforts along this line.