| Institution: | Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, MA 02115, USA |
| Abstract: | The results are presented describing the use of polymeric micelles for gamma, magnetic resonance (MR), and computed tomography (CT) imaging. Micelle-forming diacyllipid-PEG conjugates were loaded with monomeric and polymeric amphiphilic chelates, containing entrapped metals, such as 111-In or Gd, and used for the experimental gamma and MR imaging of lymphatics in rabbits. The method is described to prepare polymeric iodine-containing PEG-based micelles which may act as a long-circulating blood pool imaging agent for CT. Experimental CT-imaging performed in mice and rabbits demonstrated high potential of a micellar contrast agent. |
