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Synthesis of novel annulated uracils via domino Knoevenagel-hetero-Diels-Alder reaction in aqueous media |
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| Authors: | Malihe Javan Khoshkholgh,Hamid Reza Bijanzadeh,Jü rgen H. Gross |
| Affiliation: | a Department of Chemistry, K.N. Toosi University of Technology, PO Box 15875-4416, Tehran, Iran b Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran c Organisch-Chemisches Institut der Universitaet Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany |
| Abstract: | An efficient synthesis of tetracyclic uracil derivatives (polycyclic pyrans) is achieved via domino Knoevenagel-hetero-Diels-Alder reactions of O-propargylated salicylaldehyde derivatives with 1,3-dimethylbarbituric acid in water as solvent in the presence of CuI. The products are formed in good yields. |
| Keywords: | Domino intramolecular Knoevenagel-hetero-Diels-Alder Cuprous iodide Unactivated alkynes Aqueous media Tetracyclic uracil |
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