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Friedel-Crafts acylation of aromatic compounds with carboxylic acids in the presence of P2O5/SiO2 under heterogeneous conditions |
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| Authors: | Amin Zarei Abdol R Hajipour Leila Khazdooz |
| Institution: | a Department of Science, Islamic Azad University, Fasa Branch, PO Box No. 364, Fasa, 7461713591 Fars, Iran b Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532 WI, USA c Pharmaceutical Research Laboratory, College of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran |
| Abstract: | A convenient and efficient procedure for the Friedel-Crafts acylation of aromatic compounds with carboxylic acids in the presence of P2O5/SiO2 is described. Both aromatic and aliphatic carboxylic acids reacted easily to afford the corresponding aromatic ketones. The use of non-toxic and inexpensive materials, simple and clean work-up, short reaction times and good yields of the products are the advantages of this method. |
| Keywords: | Friedel-Crafts acylation Carboxylic acids P2O5/SiO2 |
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