| 电刺激诱发大鼠慢性颞叶癫痫模型的磁共振成像和波谱特征的研究 |
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| 引用本文： | 杨运煌,臧颖,刁芳明,韩丹,李丽云,叶朝辉,刘买利.电刺激诱发大鼠慢性颞叶癫痫模型的磁共振成像和波谱特征的研究[J].波谱学杂志,2004,21(3):281-288. |
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| 作者姓名： | 杨运煌 臧颖 刁芳明 韩丹 李丽云 叶朝辉 刘买利 |
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| 作者单位： | 波谱与原子分子物理国家重点实验室,中国科学院武汉物理与数学研究所,湖北,武汉,430071;武汉大学,医学院,生理学教研室,湖北,武汉,430071 |
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| 基金项目： | 国家自然科学基金，国家自然科学基金 |
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| 摘 要： | 应用磁共振成像(MRI)和质子定域波谱(1H-MRS)对强直流电刺激大鼠基树突区诱发慢性颞叶癫痫模型进行研究. MRI实验表明： 随着强直流电刺激时间的延长，在T2加权像(T2-MRI)中，模型大鼠的海马区腹、中侧区单侧或双侧，呈现异常高信号，扩散加权像(DWI)信号呈低信号，质子密度像无明显改变,表明T2值和表观扩散系数(ADC) 值较大的自由水比例增大. 磁共振波谱实验发现：模型大鼠T2-MRI中信号异常区与其对侧区的1H-MRS相比，NAA，PCr（包括Cr）和Cho的峰面积均无显著改变，表明在慢性颞叶癫痫模型早期1H-MRS不能检测到神经元损伤或死亡.
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| 关 键 词： | 磁共振成像 颞叶癫痫 定域活体磁共振氢谱 大鼠 |
| 文章编号： | 1000-4556(2004)03-0281-08 |
| 收稿时间： | 2004-02-11 |
| 修稿时间： | 2004年2月11日 |
CEREBRAL CHANGES DURING THE EARLY STAGE OF A RAT MODEL OF CHRONIC TEMPORAL EPILEPSY OBSERVED BY MAGNETIC RESONANCE IMAGING AND LOCALIZED IN VIVO 1H MRS |
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| YANG Yun-huang,ZANG Ying,DIAO Fang-ming,HAN Dan,LI Li-yun YE Chao-hui,LIU Mai-li State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics.CEREBRAL CHANGES DURING THE EARLY STAGE OF A RAT MODEL OF CHRONIC TEMPORAL EPILEPSY OBSERVED BY MAGNETIC RESONANCE IMAGING AND LOCALIZED IN VIVO 1H MRS[J].Chinese Journal of Magnetic Resonance,2004,21(3):281-288. |
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| Authors: | YANG Yun-huang ZANG Ying DIAO Fang-ming HAN Dan LI Li-yun YE Chao-hui LIU Mai-li State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics |
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| Institution: | 1.State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics（Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences）, Wuhan 430071,China；;
2.Department of Physiology, Medical Academy, Wuhan University, Wuhan 430071, China |
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| Abstract: | In this study, MRI and localized in vivo ~1H-MRS were applied to study cere-
bral changes during the early stage of a rat model of chronic temporal epilepsy. Epilepsy
was induced by repetitive tetanus to the right basal dendrite region. Six days after the
initial tetanus, T_2 -weighted MRI (T_2W-MRI) revealed that there was a significant in-
crease in signal intensity of the right ventral part of hippocampus, the signal intensity of
the same region decreased significantly in diffusion-weighted MRI (DWI). Such changes
may be caused by the increase of the ratio of free water to bounded water in the affected
region. Decrease of NAA was not found in the foci of epilepsy with localized in vivo ~1H-
MRS, suggesting that there existed little or no loss of neurons during the early stage of
this model of temporal epilepsy. |
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| Keywords: | MRI ~1H-MRS temporal epilepsy brain rat |
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