Role of protein kinase C in homologous desensitization of angiotensin II-induced phosphoinositide hydrolysis in rat renal mesangial cells |
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| Authors: | Josef Pfeilschifter |
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| Affiliation: | (1) Pharmaceutical Research Division, Ciba-Geigy Ltd., R-1056. P. 23, CH-4002 Basel, Switzerland |
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| Abstract: | ![]()
Conclusions These results indicate that, in rat mesangial cells, angiotensin II induces a homologous desensitization of phospholipase C stimulation. It is proposed that protein kinase C activation plays an important role in the molecular mechanism of desensitization of angiotensin II-stimulated polyphosphoinositide metabolism.
Die Rolle der Proteinkinase C bei der homologen Desensitisierung der Angiotensin II stimulierten Hydrolyse von Phosphoinositiden |
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