A serendipitous conversion of enaminolactone nitriles with primary amines: a new synthesis of substituted 2-aminopyridine derivatives |
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| Authors: | Nawel Cheikh Didier Villemin Nathalie Bar Jean-François Lohier Nourredine Choukchou-Braham Bachir Mostefa-Kara Jana Sopkova |
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| Institution: | 1. Laboratoire de Chimie Moléculaire et Thioorganique, UMR CNRS 6507, INC3M, FR 3038, ENSICAEN et Université de Caen Basse-Normandie, 14050 Caen, France;2. Laboratoire de Catalyse et Synthèse en Chimie Organique, Faculté des Sciences, Université Abou-Bakr Belkaid, BP 119, 13000 Tlemcen, Algeria;3. Université de Béchar, Faculté des Sciences et Technologies, BP 417, 08000 Béchar, Algeria;4. Centre d''Etudes et de Recherche sur le Médicament de Normandie (CERMN), Université de Caen, boulevard Henri Becquerel, F-14032 Caen, France |
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| Abstract: | In the course of our studies on Cerpegin analogues synthesis, a serendipitous reactivity of enaminolactone nitrile has been observed. Instead of expecting iminocerpegins, we have gained new class of substituted 2-aminopyridines. The methodology has been applied on a wide range of primary amines, as aliphatic, aromatic, heteroaromatic and also, diamines, hydrazines and chiral amines. |
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