Synthesis of Novel Imidazo[1,2‐a]pyridin‐2‐amines from Arylamines and Nitriles via Sequential Addition and I2/KI‐Mediated Oxidative Cyclization |
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| Authors: | Xianhai Tian Lina Song Manman Wang Zhigang Lv Dr Jie Wu Dr Wenquan Yu Prof?Dr Junbiao Chang |
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| Institution: | 1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, P. R. China;2. Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province, Zhengzhou, P. R. China |
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| Abstract: | A novel and practical strategy for the construction of imidazo1,2‐a]pyridin‐2‐amine frameworks has been developed. The present sequential approach involves addition of arylamines to nitriles and I2/KI‐mediated oxidative C?N bond formation without purification of the intermediate amidines. This operationally simple synthetic process provides a facile access to a variety of new 2‐amino substituted imidazo1,2‐a]pyridines and related heterocyclic compounds in an efficient and scalable fashion. |
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| Keywords: | C− N bond formation iodine imidazo[1 2-a]pyridin-2-amine oxidative cyclization sequential synthesis |
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