A novel entry into a new class of spiroheterocyclic framework: regioselective synthesis of dispiro[oxindole-cyclohexanone]pyrrolidines and dispiro[oxindole-hexahydroindazole]pyrrolidines |
| |
Authors: | A Amal Raj R Raghunathan |
| |
Institution: | Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai 600 025, India |
| |
Abstract: | 2,6-Bis(arylmethylidene)cyclohexanones undergo a regioselective 1,3-dipolar cycloaddition reaction with the azomethine ylide derived from isatin and sarcosine by a decarboxylative route affording a series of 1-N-methyl-spiro2.31]oxindole-spiro3.211]611-arylmethylidenecyclohexanone-4-aryl-pyrrolidines which were further annulated to give a series of novel 1-N-methyl-spiro2.31]oxindole-spiro3.711](311-aryl)Δ111,711a-hexahydro-2H-indazole-4-aryl-pyrrolidines. The structures of which were established by spectroscopic techniques as well as single crystal X-ray analysis. |
| |
Keywords: | 1 3-dipolar cycloaddition 2 6-bis(arylmethylidene)cyclohexanones decarboxylative route isatin sarcosine dispiropyrrolidines |
本文献已被 ScienceDirect 等数据库收录! |