Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells |
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| Authors: | Ciobanu Mihai Huang Kuo-Ting Daguer Jean-Pierre Barluenga Sofia Chaloin Olivier Schaeffer Evelyne Mueller Christopher G Mitchell Daniel A Winssinger Nicolas |
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| Institution: | Institut de Science et Ingenierie Supramoleculaires (ISIS), Université de Strasbourg-CNRS, 8 allee Gaspard Monge, 67000 Strasbourg, France. |
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| Abstract: | We report the synthesis of a nucleic acid-encoded carbohydrate library, its combinatorial self-assembly into 37,485 pairs and a screen against DC-SIGN leading to the identification of consensus ligand motifs. A prototypical example from the selected pairs was shown to have enhanced binding. A dendrimer incorporating the selected motifs inhibited gp120's binding to dendritic cells with higher efficiency than mannan. |
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