Analysis of dissolution test sample solutions by high speed capillary electrophoresis |
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Authors: | K D Altria E Traylen N Turner |
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Institution: | (1) Glaxo Research and Development, Pharmacy Division, Park Road, SG12 ODP Ware, Herts, UK |
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Abstract: | Summary The quantitative use of high speed capillary electrophoresis (HSCE) is examined by applying high voltages across short capillaries.
Acceptable performance in terms of injection precision and migration times were achieved within 1–2 minute analysis times.
HSCE was used for the novel CE application of dissolution test sample solution analysis. The results generated by HSCE compared
well with those generated using validated on-line UV absorbance measurements. It is concluded that HSCE is a viable alternative
and supplement to standard analytical methods employed in dissolution test analysis. |
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Keywords: | Capillary electrophoresis High speed analysis Dissolution testing Pharmaceuticals |
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